 | | 姓名： | 严晓文 | 职称： | 副教授/博士生导师 | | 电话： | 0592-2181796 | E-mail： | xwyan@xmu.edu.cn | | 研究方向： | | | 1. 设计合成多功能分子探针用于生物分子的鉴定与定量分析
2. 复杂生物体系中的分子相互作用研究
3. 生物偶联技术、核酸分析、基因编辑、药物输送等 |
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2019年4月至今 厦门大学 化学系 副教授、特任研究员
2013年-2019年 加拿大 阿尔伯塔大学 医学院 博士后
2007年-2012年 厦门大学 化学系 分析化学专业 理学博士
2003年-2007年 厦门大学 化学系 化学生物学专业 理学学士
近期论文： 1. Xinyue Zhao,# Naijie Wei,# Ziyang Fang, Yingyan Xie, Xiaowen Yan,* and Qiuquan Wang. A Targeted Covalently Activated Chemotherapy Strategy Synergistically Enhances Cytotoxicity of Ibrutinib and Selectivity of Doxorubicin to B‑cell Lymphoma Cells. J. Med. Chem. 2026, 69, 2387−2399.
2. Xinyue Zhao,# Yang Zhao,# Ziyang Fang,# Naijie Wei, Jianbin Chen, Qiuquan Wang, and Xiaowen Yan.* Antibody-Targeted Covalent Inhibitor Conjugate (Ab-TCI) Bridged by an Arsenic-Thiol Bond Enables “Double Insurance” Targeting of Cancer Cells and Kinase for Effective Cancer Treatment. ACS Med. Chem. Lett. 2026, DOI: 10.1021/acsmedchemlett.6c00131.
3. Naijie Wei, Xiaowen Yan,* Mingyue Yu, Rong Li, Zhixin Xiao, Shi Chen, Limin Yang, Qiuquan Wang,* Qian Liu, and Guibin Jiang. Binding of N‑(1,3-Dimethylbutyl)-N’-phenyl‑p‑phenylenediamine Quinone (6PPDQ) to Mitochondrial Proteins Provokes Mitochondria Dysfunction. Chem. Res. Toxicol. 2026, 39, 283−292.
4. Haowen Hu, Zhengxian Lv, Yixin Guo, Li Yi, Limin Yang, Xiaowen Yan,* Qiuquan Wang.* Site-specific conjugated antibody-element tags for single-cell ICP-MS. Talanta, 2026, 300, 129227.
5. Xiaokang Guan, Qiao Lu, Shuxian Liu, Xiaowen Yan*. Postionization Mass Spectrometry Imaging: Past, Present, and Future, Mass Spectrom. Rev. 2026, 45(2), 231-43. (IF=7.9, 厦门大学，JCR 1区)
6. Lizhen Yan, Wenxi Fang, Huamin Li, Xiaowen Yan, Shi Chen, Limin Yang, and Qiuquan Wang.* Photocatalytic Atomization of the Elemental Species in Solution for Atomic Fluorescence Spectrometry. J. Am. Chem. Soc. 2026, 148, 13682−13688.
7. Lizhen Yan, Wenxi Fang, Huamin Li, Xiaowen Yan, Shi Chen, Limin Yang, and Qiuquan Wang* Photocatalytic Atomization of the Elemental Species in Solution for Atomic Fluorescence Spectrometry. J. Am. Chem. Soc. 2026, 148, 13682-13688.
8. Xinyue Zhao, Yuxin Gu, Yingyan Xie, Naijie Wei, Ziyang Fang, Xiaowen Yan,* Qiuquan Wang. A BTK-Activatable Targeted Covalent NIR Fluorescent Probe for Kinase Monitoring and B-cell Lymphoma Imaging, Biosens. Bioelectron., 2025, 117867. (IF=10.5, 厦门大学，JCR 1区)
9. Zhiyang Fang, Xinyue Zhao, Ruxue Hou, Yang Zhao, Lei Wang, Li Yi, Limin Yang, Xiaowen Yan,* Qiuquan Wang. Antibody Directed Cell Internalization of Targeted Covalent Lanthanide Tag Enables In-situ Kinase Labeling and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) Quantification. Anal. Chem. 2025, 97, 12125−12132. (IF=6.8, 厦门大学，JCR 1区)
10. Xiaokang Guan, Qiao Lu, Naijie Wei, Shuxian Liu, Haowen Li, Qin Wu, Xiaowen Yan,* Renato Zenobi*. Multiplexed Detection of Tumor Markers and Discrimination of Cancer Cell Types by Laser Ablation-Dielectric Barrier Discharge Ionization-Mass Spectrometry. Anal. Chem. 2025, 97, 9276−9283. (IF=6.8, 厦门大学，JCR 1区)
11. Xiaokang Guan, Chencheng Wei, Xiaowen Yan,* Renato Zenobi*. Optimization of Dielectric Material Improves Ionization Capability and Mass Range of Dielectric Barrier Discharge Ionization Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2025, 36, 8, 1812–1820. (IF=2.8, 厦门大学，JCR 3区)
12. Xue Liu, Wenjing Ning, Lei Wang, Han Liu, Hongye Zeng, Xiaojing Qin, Yuanzhi Chen, Fentian Chen, Lin Xu, Yang Zhao, Xiaoqing Chen, Jixian Tang, Yunlong Ren, Xiaowen Yan,* Wenxin Luo,* Ningshao Xia*. Engineering heavy chain antibody‐drug conjugates against solid tumors for a one‐shot kill, Cancer Commun. 2024, 44, 1444–1448. (IF=20.1, 厦门大学，JCR 1区)
13. Yang Zhao, Xinyue Zhao, Lewei Duan, Ruxue Hou, Yuxin Gu, Zhen Liu, Jianbin Chen, Feizhen Wu, Limin Yang, X. Chris Le, Qiuquan Wang, and Xiaowen Yan*. Reinvent Aliphatic Arsenicals as Reversible Covalent Warheads toward Targeted Kinase Inhibition and Non-acute Promyelocytic Leukemia Cancer Treatment. J. Med. Chem. 2024, 67, 5458–5472. (IF=6.9, 厦门大学，JCR 1区)
14. Zhengxian Lv, Xinli Yan, Zhen Liu, Shi Chen, Xiaowen Yan,* Limin Yang, Qiuquan Wang*. A CH4-Driven Ion Cloud-Stretched Approach Enables ICPqMS for Multiplex Single-Cell Analysis. Chem. Eur. J. 2024, 30 (71), e202402289. (IF=4.1, 厦门大学，JCR 2区)
15. Ruxue Hou, Yuxin Gu, Yang Zhao, Xinyue Zhao, Limin Yang, Xiaowen Yan,* and Qiuquan Wang. Covalent Targeting Drug Mediated Specific Lanthanide Tagging Towards In Situ Bruton's Tyrosine Kinase Quantification Using ICP-MS. At. Spectrosc. 2024, 45, 74–82. (IF=3.4, 厦门大学，JCR 2区)
16. Jianyu Hu, Xiaowen Yan,* X. Chris Le*. Label‑free detection of biomolecules using inductively coupled plasma mass spectrometry (ICP‑MS), Anal. Bioanal. Chem. 2024, 416, 2625–2640. (IF=3.8, 阿尔伯塔大学，JCR 2区)
17. Xiangxu Zhao, Xiaokang Guan, Qiao Lu, Xiaowen Yan,* and Renato Zenobi*. Rapid detection of aflatoxin B1, zearalenone and ochratoxin A in grains by thermal desorption dielectric barrier discharge ionization mass spectrometry, Analyst, 2024, 149, 5034-5040. (IF=3.6, 厦门大学，JCR 2区)
18. Xiaokang Guan, Qiao Lu, Xiangxu Zhao, Xiaowen Yan,* and Renato Zenobi*. Spatio-Temporal Analysis of Anesthetics in Mice by Solid-Phase Microextraction: Dielectric Barrier Discharge Ionization Mass Spectrometry. Anal. Chem. 2023, 95, 12470–12477. (IF=6.8, 厦门大学，JCR 1区)
19. Xin Jin, Limin Yang,* Xiaowen Yan,* and Qiuquan Wang*. Screening Platform Based on Inductively Coupled Plasma Mass Spectrometry for β-Site Amyloid Protein Cleaving Enzyme 1 (BACE1) Inhibitors. ACS Chem. Neurosci. 2021, 12, 1093–1099. (IF=4.2, 厦门大学，JCR 2区)
20. Xiaowen Yan, X. Chris Le*. Fluorescence imaging of Cu(I) in endoplasmic reticulum of live cells and tissue, Sci. China Chem. 2019, 62, 887–888. (IF=10.4, 厦门大学，JCR 1区)
21. 谢莹滟, 赵鑫悦, 方自扬, 魏奶杰, 彭欣冉, 严晓文*, 王秋泉. 基于单颗粒电感耦合等离子体质谱（SP-ICP-MS）和泊松分布原理的DNA单分子计数. 中国无机分析化学, 2026, (doi:11.6005.O6.20251116.1646.002.)
22. 王蕾, 易立, 李华敏, 陈石, 杨利民, 严晓文,* 王秋泉*. 基于多肽亲和介导定点偶联策略的抗体元素标签的合成及单细胞分析应用, 分析化学, 2024, 52(10), 1496–1507. 厦门大学
23. 余明月, 魏奶杰, 严晓文,* 陈石, 陈建彬, 杨利民, 王秋泉*. 环境化学研究中的质谱方法, 质谱学报, 2023, 44, 170–180. 厦门大学
24. 严晓文, 张博, 杨利民, 陈石, 王秋泉*. 从原子到分子和细胞的电感耦合等离子体质谱绝对定量分析, 厦门大学学报.自然科学版, 2021, 60(2), 169–177. 厦门大学
近期项目：
1. 2025J0101，发展基于电感耦合等离子体质谱的单分子检测技术，福建省自然科学基金面上项目，2025.09.01-2028.08.31，10万元，项目负责人
2. 22074127，砷与其蛋白质靶点相互作用亲和力的金属组学研究，国家自然科学基金面上项目，2021.01.01-2024.12.31，63万元，项目负责人
3. 2022YFF0710202，基于新型纳米结构的元素标记探针开发，国家重点研发计划子课题，2022.11.01-2025.10.31，100万元，子课题负责人
4. 22193053，外源污染物的毒性与生理扰动分子机制，国家自然科学基金重大项目课题，2022.01.01-2026.12.31，498万元（分割经费140万元），研究骨干
5. HRTP-[2022]-13，元素质谱标签试剂研制，嘉庚创新实验室人才培育项目，2022.01.01-2023.12.31，50万元，项目负责人
6. 20720200073，砷-巯基亲和力可控分子标签的开发与砷结合蛋白金属组学研究，厦门大学校长基金，2022.01.01-2023.12.31，50万元，项目负责人
