主要研究成果
近年来，在 NSFC、973、863 等科研基金的资助下，本研究小组针对典型污染元素和持久性有机污染物在环境介质中的含量和化学形态分析方法学以及植物抵御污染环境胁迫的调控机制，系统地展开了以色谱-原子光谱/质谱联用检测技术为主要手段的基础和应用基础研究。其中主要研究成果包括：
（1）革新了传统原子光谱/质谱进样方式和色谱联用接口技术。率先报道了纳米氧化钛光催化导带电子和巯基乙醇光诱导S.还原的光催化/光诱导化学蒸气发生新原理，并用于硒和汞的形态分析；发展了基于热扩散原理的程序升温式热扩散GC/ICP-MS接口新技术，并用于汞和铅多形态同时分析；发展了cGC/ECNI-MS的脉冲式大体积进样新技术及其耦合新方法，并用于典型卤代持久性有机污染物（H-POPs）的高灵敏准确分析；自主设计和研制了相关便携式分析仪器和部件，最大限度地释放分析仪器的检测能力，并成功应用于野外环境现场检测。
（2）发展和丰富了生物分子检测策略，提出并建立了以元素为标签的生物标志分子的原子光谱/元素质谱筛选和定量方法，应用于硒蛋白和汞标记蛋白的筛选和绝对定量分析。
（3）利用所发展的HPLC/ICP-qMS/ESI-IT-MS联用新技术，首次发现并鉴定了在体镉、汞诱导的植物螯合肽（PCs）配合物in-vivo PCs-Cd和PCs-Hg，给出了植物抵御细胞氧化机制中PCs络合钝化设想长期缺乏的实验证据。
（4）率先提出树木“时间隧道”和“自然内标”概念、发展了系统的分析检测方法，建立了大气与树木表皮间POPs分配模型，填补了我国大气POPs污染空间分布和历史演变数据的空白。
已发表论文
| 113 | A CH4-Driven Ion Cloud-Stretched Approach Enables ICP-qMS for Multiplex Single-Cell Analysis, Chemistry-A European Journal, 2024, 30(71): e202402289 |  |
| 112 | 基于多肽亲和介导定点偶联策略的抗体元素标签的合成及单细胞分析应用, 分析化学, 2024, 52(10): 1496-1507 | |
| 111 | Covalent Targeting Drug Mediated Specific Lanthanide Tagging Towards In Situ Bruton's Tyrosine Kinase Quantification Using ICP-MS, Atomic Spectroscopy, 2024, 45(2): 74-82 | |
| 110 | Single cell glycan-linkages profiling for hepatocellular carcinoma early diagnosis using lanthanide encoded bacteriophage MS2 based ICP-MS, Talanta, 2024, 274: 126056 | |
| 109 | Reinvent Aliphatic Arsenicals as Reversible Covalent Warheads toward Targeted Kinase Inhibition and Non-acute Promyelocytic Leukemia Cancer Treatment, Journal of Medicinal Chemistry, 2024, 67(7): 5458-5472 | |
| 108 | Design of a dual Ir-Eu tag for fluorescent visualization and ICP-MS quantification of SIRPα and its host cells, Analytical and Bioanalytical Chemistry, 2024, 416(11): 2691-2697 | |
| 107 | Zero-Interfacing μHPLC to ICPMS, Analytical Chemistry, 2022, 94(49): 16975-16979 | |
| 106 | Quantification of active selenols in cells: a selenol-specific recognition europium-switched signal-amplification ICP-MS approach, Analytical and Bioanalytical Chemistry, 2022, 414(1): 257-263(SI) | |
| 105 | Multivalent Duplexed-Aptamer Networks Regulated a CRISPR-Cas12a System for Circulating Tumor Cell Detection, Analytical Chemistry, 2021, 93(38): 12921-12929 | |
| 104 | Single-cell fucosylation breakdown: Switching fucose to europium, iScience, 2021, 24(5): 102397 | |
| 103 | Screening Platform Based on Inductively Coupled Plasma Mass Spectrometry for beta-Site Amyloid Protein Cleaving Enzyme 1 (BACE1) Inhibitors, ACS Chemical Neuroscience, 2021, 12(7): 1093-1099 | |
| 102 | 从原子到分子和细胞的电感耦合等离子体质谱绝对定量分析, 厦门大学学报（自然科学版）, 2021, 60(2): 169-177 | |
| 101 | DNAzyme-Au nanoprobe coupled with graphene-oxide-loaded hybridization chain reaction signal amplification for fluorometric determination of alkaline phosphatase, Microchimica Acta, 2021, 188(1): 7 | |
| 100 | Orderly MOF-Assembled Hybrid Monolithic Stationary Phases for Nano-Flow HPLC, Analytical Chemistry, 2020, 92(24): 15757-15765 | |
| 99 | A Biochemical Lanthanide-Encoding Approach Enables Quantitative Monitoring of the Bacterial Response to Vancomycin Treatment, Biochemistry, 2020, 59(38): 3523-3528 | |
| 98 | Direct Infusion ICP-qMS of Lined-up Single-Cell Using an Oil-Free Passive Microfluidic System, Analytical Chemistry, 2020, 92(7): 5286-5293 | |
| 97 | Towards a high peak capacity of 130 using nanoflow hydrophilic interaction liquid chromatography, Analytica Chimica Acta, 2019, 1062: 147-155 | |
| 96 | A novel double-modified strategy to enhance the performance of thin-film nanocomposite nanofiltration membranes: Incorporating functionalized graphenes into supporting and selective layers, Chemical Engineering Journal, 2019, 368: 186-201 | |
| 95 | Counting and Recognizing Single Bacterial Cells by a Lanthanide-Encoding Inductively Coupled Plasma Mass Spectrometric Approach, Analytical Chemistry, 2019, 91(13): 8341-8349 | |
| 94 | Fluorescent and mass spectrometric evaluation of the phagocytic internalization of a CD47-peptide modified drug-nanocarrier, Analytical and Bioanalytical Chemistry, 2019, 411(18): 4193-4202(SI) | |
| 93 | Inhibitory Covalent Labeling and Clickable-Eu-Tagging-Based ICPMS: Measurement of pH-Dependent Absolute Activities of the Cathepsins in Hepatocyte Lysosomes, Analytical Chemistry, 2019, 91(11): 7032-7038 | |
| 92 | Viruslike Element-Tagged Nanoparticle Inductively Coupled Plasma Mass Spectrometry Signal Multiplier: Membrane Biomarker Mediated Cell Counting, Analytical Chemistry, 2019, 91(8): 4948-4952 | |
| 91 | Electrochromatographic behavior of core-shell particles: A comparison study, Analytica Chimica Acta, 2018, 1033: 205-212 | |
| 90 | Dual polyhedral oligomeric silsesquioxanes polymerization approach to mutually-mediated separation mechanisms of hybrid monolithic stationary and mobile phases towards small molecules, Journal of Chromatography A, 2018, 1533: 136-142 | |
| 89 | Near-Infrared Neodymium Tag for Quantifying Targeted Biomarker and Counting Its Host Circulating Tumor Cells, Analytical Chemistry, 2017, 89(17): 9239-9246 | |
| 88 | Step-by-Step Design and Synthesis of Au@SiO2@Phenyl-azathiacrown for SERS-Based Specific Quantification of Inorganic Mercury, ChemistryOpen, 2017, 6(2): 201-205 | |
| 87 | Enhancing the performance of thin-film nanocomposite nanofiltration membranes using MAH-modified GO nanosheets, RSC Advances, 2017, 7(86): 54898-54910 | |
| 86 | Preparation and characterization of novel alkali-resistant nanofiltration membranes with enhanced permeation and antifouling properties: the effects of functionalized graphene nanosheets, RSC Advances, 2017, 7(30): 18755-18764 | |
| 85 | ICPMS-Based Specific Quantification of Phosphotyrosine: A Gallium Tagging and Tyrosine-Phosphatase Mediated Strategy, Analytical Chemistry, 2016, 88(20): 9890-9896 | |
| 84 | Silica-based polypeptide-monolithic stationary phase for hydrophilic chromatography and chiral separation, Journal of Chromatography A, 2016, 1446: 125-133 | |
| 83 | An ongoing path of element-labeling/tagging strategies toward quantitative bioanalysis using ICP-MS, Applied Spectroscopy Reviews, 2016, 51(2): 117-128 | |
| 82 | A Newly Identified Passive Hyperaccumulator Eucalyptus grandis x E. urophylla under Manganese Stress, PLoS One, 2015, 10(9): e0136606 | |
| 81 | Two dimensional separations of human urinary protein digest using a droplet-interfaced platform, Analytica Chimica Acta, 2015, 863: 86-94 | |
| 80 | Quantification and visualization of glutathione S-transferase omega 1 in cells using inductively coupled plasma mass spectrometry (ICP-MS) and fluorescence microscopy, Analytical and Bioanalytical Chemistry, 2015, 407(9): 2373-2381 | |
| 79 | Determination and speciation of Hg using HPLC-AFS by atomization of this metal on a UV/nano-ZrO2/HCOOH photocatalytic reduction unit, Journal of Analytical Atomic Spectrometry, 2015, 30(4): 916-921 | |
| 78 | Towards high peak capacity separations in normal pressure nanoflow liquid chromatography using meter long packed capillary columns, Analytica Chimica Acta, 2014, 852: 267-273 | |
| 77 | A comparison study of in-column and on-column detection for electrochromatography, Journal of Chromatography A, 2014, 1362: 225-230 | |
| 76 | Evaluation of BDE-47 Hydroxylation Metabolic Pathways Based on a Strong Electron-Withdrawing Pentafluorobenzoyl Derivatization Gas Chromatography/Electron Capture Negative Ionization Quadrupole Mass Spectrometry, Environmental Science & Technology, 2014, 48(14): 8117-8126 | |
| 75 | Fabrication and investigation of electrochromatographic columns with a simplex configuration, Journal of Chromatography A, 2014, 1349: 90-95 | |
| 74 | EphA2 enhances the proliferation and invasion ability of LNCaP prostate cancer cells, Oncology Letters, 2014, 8(1): 41-46 | |
| 73 | A chemical “hub” for absolute quantification of a targeted protein: orthogonal integration of elemental and molecular mass spectrometry, Chemical Communications, 2014, 50: 6578-6581 | |
| 72 | Click Chemistry Mediated Eu-Tagging: Activity-Based Specific Quantification and Simultaneous Activity Evaluation of CYP3A4 Using Eu-153 Species-Unspecific Isotope Dilution Inductively Coupled Plasma Mass Spectrometry, Analytical Chemistry, 2014, 86(8): 3688-3692 | |
| 71 | Toward rapid preparation of capillary columns for electrochromatography use, Electrophoresis, 2014, 35(6): 836-839 | |
| 70 | A "plug-and-use" approach towards facile fabrication of capillary columns for high performance nanoflow liquid chromatography, Journal of Chromatography A, 2014, 1325: 109-114 | |
| 69 | ICP-MS-Based Multiplex and Ultrasensitive Assay of Viruses with Lanthanide-Coded Biospecific Tagging and Amplification Strategies, Analytical Chemistry, 2013, 85(20): 9428-9432 | |
| 68 | Detection and quantification of proteins and cells by use of elemental mass spectrometry: progress and challenges, Analytical and Bioanalytical Chemistry, 2013, 405(17): 5663-5670 | |
| 67 | Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn7MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS, Metallomics, 2013, 5(7): 855-860 | |
| 66 | Performance of single particle fritted capillary columns in electrochromatography, Journal of Chromatography A, 2013, 1272: 136-140 | |
| 65 | Studies of biouptake and transformation of mercury by a typical unicellular diatom Phaeodactylum tricornutum, Chinese Science Bulletin, 2013, 58(2): 256-265 | |
| 64 | Synthesis and characterization of a high selective mercury(II)-imprinted polymer using novel aminothiol monomer, Talanta, 2012, 101: 261-266 | |
| 63 | Integrin-Targeted Trifunctional Probe for Cancer Cells: A "Seeing and Counting" Approach, Analytical Chemistry, 2012, 84(21): 8946-8951 | |
| 62 | A Way to Probe the Microenvironment of Free Sulfhydryls in Intact Proteins with a Series of Monofunctional Organic Mercurials, Chemistry-A European Journal, 2012, 18(44): 13989-13993 | |
| 61 | Europium-Labeled Activity-Based Probe through Click Chemistry: Absolute Serine Protease Quantification Using 153Eu Isotope Dilution ICP/MS, Angewandte Chemie-International Edition, 2012, 51(14): 3358-3363 | |
| 60 | Nanosemiconductor-Based Photocatalytic Vapor Generation Systems for Subsequent Selenium Determination and Speciation with Atomic Fluorescence Spectrometry and Inductively Coupled Plasma Mass Spectrometry, Analytical Chemistry, 2012, 84(6): 2974-2981 | |
| 59 | "One-pot" preparation of basic amino acid-silica hybrid monolithic column for capillary electrochromatography, Journal of Separation Science, 2011, 34(16-17): SI2314-2322 | |
| 58 | A dual-labelling strategy for integrated ICPMS and LIF for the determination of peptides, Journal of Analytical Atomic Spectrometry, 2011, 26(6): 1175-1177 | |
| 57 | Mechanisms of chemical generation of volatile hydrides for trace element determination (IUPAC Technical Report), Pure and Applied Chemistry, 2011, 83(6): 1283-1340 | |
| 56 | Lanthanide-Coded Protease-Specific Peptide–Nanoparticle Probes for a Label-Free Multiplex Protease Assay Using Element Mass Spectrometry: A Proof-of-Concept Study, Angewandte Chemie-International Edition, 2011, 50(22): 5130-5133 | |
| 55 | Strategies for Protein Quantification by Integrated Elemental and Molecular Mass Spectrometry, Clinical Chemistry and Laboratory Medicine, 2011, 49: S137 | |
| 54 | Evaluation of cadmium species lability using ion-pair reversed phase HPLC coupled on-line with inductively coupled plasma mass spectrometry, Talanta, 2011, 84(2): 287-292 | |
| 53 | Free cadmium ions released from CdTe-based nanoparticles and their cytotoxicity on Phaeodactylum tricornutum, Metallomics, 2010, 2(7): 469-473 | |
| 52 | SE-HPLC/ICP-MS/ESI-MS联用技术用于富镉植物中镉的形态研究, 光谱学与光谱分析, 2010, 30(4): 1096-1100 | |
| 51 | Dynamic Labeling Strategy with Hg-204-Isotopic Methylmercurithiosalicylate for Absolute Peptide and Protein Quantification, Analytical Chemistry, 2010, 82(5): 1616-1620 | |
| 50 | Absolute Quantification of Intact Proteins via 1,4,7,10-Tetraazacyclododecane-1,4,7-trisacetic acid-10-Maleimidoethylacetamide-Europium Labeling and HPLC Coupled with Species-Unspecific Isotope Dilution ICPMS, Analytical Chemistry, 2010, 82(4): 1261-1269 | |
| 49 | Bioaccumulation and transformation of cadmium by Phaeodactylum tricornutum, Science in China Series B: Chemistry, 2009, 52(12): 2373-2380 | |
| 48 | The determination of low-molecular-mass thiols with 4-(hydroxymercuric)benzoic acid as a tag using HPLC coupled online with UV/HCOOH-induced cold vapor generation AFS, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2009, 877(28): 3428-3433 | |
| 47 | Strategy for absolute quantification of proteins: CH3Hg+ labeling integrated molecular and elemental mass spectrometry, Journal of Analytical Atomic Spectrometry, 2009, 24(9): 1184-1187 | |
| 46 | Different alkyl dimethacrylate mediated stearyl methacrylate monoliths for improving separation efficiency of typical alkylbenzenes and proteins, Journal of Chromatography A, 2009, 1216(15): 3098-3106 | |
| 45 | In vivo phytochelatins and Hg-phytochelatin complexes in Hg-stressed Brassica chinensis L., Metallomics, 2009, 1(1): 101-106 | |
| 44 | 单叶新月蕨稀土富集能力与结合多肽结构研究, 中国稀土学报, 2009, 27(2): 289-296 | |
| 43 | Quantification of selenium-tagged proteins in human plasma using species-unspecific isotope dilution ICP-DRC-qMS coupled on-line with anion exchange chromatography, Journal of Analytical Atomic Spectrometry, 2008, 23(11): 1545-1549 | |
| 42 | Counting sulfhydryls and disulfide bonds in peptides and proteins using mercurial ions as an MS-tag, Journal of the American Society for Mass Spectrometry, 2008, 19(8): 1108-1113 | |
| 41 | Modeling persistent organic pollutant (POP) partitioning between tree bark and air and its application to spatial monitoring of atmospheric POPs in mainland China, Environmental Science & Technology, 2008, 42(16): 6046-6051 | |
| 40 | Alternative thermodiffusion interface for simultaneous speciation of organic and inorganic lead and mercury species by capillary GC-ICPMS using tri-n-propyl-lead chloride as an internal standard, Analytical Chemistry, 2008, 80(15): 6104-6109 | |
| 39 | Synergistic defensive mechanism of phytochelatins and antioxidative enzymes in Brassica chinensis L. against Cd stress, Chinese Science Bulletin, 2008, 53(10): 1503-1511 | |
| 38 | 闽江水体镉的络合容量和配合物易变常数, 环境化学, 2008, 27(6): 795-799 | |
| 37 | SEC-ICP-MS and ESI-MS/MS for analyzing in vitro and in vivo Cd-phytochelatin complexes in a Cd-hyperaccumulator Brassica chinensis, Journal of Analytical Atomic Spectrometry, 2007, 22(11): 1403-1408 | |
| 36 | Pulsed large volume injection gas chromatography coupled with electron-capture negative ionization quadrupole mass spectrometry for simultaneous determination of typical halogenated persistent organic pollutants, Journal of the American Society for Mass Spectrometry, 2007, 18(8): 1375-1386 | |
| 35 | A new vapor generation system for mercury species based on the UV irradiation of mercaptoethanol used in the determination of total and methyl mercury in environmental and biological samples by atomic fluorescence spectrometry, Analytical and Bioanalytical Chemistry, 2007, 388(4): 831-836 | |
| 34 | Determination of cadmium in seawater by vapor generation atomic fluorescence spectrometry after online preconcentration with a novel alkyl phosphinic acid resin, Spectroscopy Letters, 2007, 40(3): 547-557 | |
| 33 | On-line preconcentration with a novel alkyl phosphinic acid extraction resin coupled with inductively coupled plasma mass spectrometry for determination of trace rare earth elements in seawater, Talanta, 2007, 72(4): 1248-1254 | |
| 32 | Vapour generation at a UV/TiO2 photocatalysis reaction device for determination and speciation of mercury by AFS and HPLC-AFS, Journal of Analytical Atomic Spectrometry, 2007, 22(3): 330-334 | |
| 31 | Alternative normalization method of atmospheric polycyclic aromatic hydrocarbons pollution level recorded by tree bark, Environmental Science & Technology, 2006, 40(19): 5853-5859 | |
| 30 | 硒形态分析研究进展, 光谱学与光谱分析, 2006, 26(9): 1692-1701 | |
| 29 | On-line pre-reduction of Se(VI) by thiourea for selenium speciation by hydride generation, Spectrochimica Acta Part B-Atomic Spectroscopy, 2006, 61(7): 803-809 | |
| 28 | Subcellular distribution of rare earth elements and characterization of their binding species in a newly discovered hyperaccumulator Pronephrium simplex, Talanta, 2006, 70(1): 26-31 | |
| 27 | Preparation and evaluation of stable coating for capillary electrophoresis using coupled chitosan as coated modifier, Talanta, 2006, 69(2): 463-468 | |
| 26 | 植物——实时富集大气持久性有机污染物的被动采样平台, 环境化学, 2005, 24(3): 233-240 | |
| 25 | Chiral speciation and determination of DL-Selenomethionine enantiomers on a novel chiral ligand-exchange stationary phase, Analytical Sciences, 2005, 21(3): 253-257 | |
| 24 | 镧在菠菜叶绿体中的分布及其对光合作用的影响, 科学通报, 2005, 50(12): 1195-1200 | |
| 23 | 生物体系中硒代氨基酸的手性形态分析进展, 分析化学, 2005, 33(9): 1330-1334 | |
| 22 | Preliminary study of the enrichment and fractionation of REEs in a newly discovered REE hyperaccumulator Pronephrium simplex by SEC-ICP-MS and MALDI-TOF/ESI-MS, Journal of Analytical Atomic Spectrometry, 2005, 20(8): 751-753 | |
| 21 | 用酰胺型键合固定相测定茶叶中嘌呤碱含量, 分析化学, 2005, 33(5): 627-630 | |
| 20 | 辛基型毛细管液相色谱整体柱的制备、表征及评价, 分析化学, 2005, 33(4): 467-470 | |
| 19 | L-异亮氨酸型配体交换固定相对DL-氨基酸的拆分研究, 色谱, 2005, 23(2): 172-175 | |
| 18 | Electrochemical vapor generation of selenium species after online photolysis and reduction by UV-irradiation under nano TiO2 photocatalysis and its application to selenium speciation by HPLC coupled with atomic fluorescence spectrometry, Analytical and Bioanalytical Chemistry, 2005, 381(2): 366-372 | |
| 17 | Octyl-type monolithic columns of 530 mu m i.d. for capillary liquid chromatography, Journal of Chromatography A, 2005, 1062(2): 183-188 | |
| 16 | Historical records of airborne polycyclic aromatic hydrocarbons by analyzing dated corks of the bark pocket in a Longpetiole Beech tree, Environmental Science & Technology, 2004, 38(18): 4739-4744 | |
| 15 | Online pre-reduction of selenium(VI) with a newly designed UV/TiO2 photocatalysis reduction device, Journal of Analytical Atomic Spectrometry, 2004, 19(6): 715-716 | |
| 14 | Concentrations of hazardous heavy metals in environmental samples collected in Xiamen, China, as determined by vapor generation non-dispersive atomic fluorescence spectrometry, Analytical Sciences, 2004, 20(1): 85-88 | |
| 13 | Chromatographic behavior of cadmium in an ion-pair reversed-phase micro HPLC system and its application to the determination of bio-available cadmium in soil samples, Analytical and Bioanalytical Chemistry, 2003, 376(6): 923-927 | |
| 12 | 利用‘树皮'进行大气污染历史监测的新采样方法(英文), 环境化学, 2003, 22(3): 250-254 | |
| 11 | 高效液相色谱-原子荧光光谱联用中的连续数字信号采集和处理, 光谱学与光谱分析, 2003, 23(2): 354-357 | |
| 10 | 日本大学分析化学教育现状简介与借鉴, 大学化学, 2002, 17(5): 57-61 | |
| 9 | 环境样品中生物可利用态镉的反相离子对-HPLC-荧光检测, 高等学校化学学报, 2002, 23(9): 1692-1694 | |
| 8 | Determination of Trace Impurities in High Purity Gallium by ICP-MS after Bis(1,1,3,3-tetramethylbutyl) dithiophosphinic Acid Extractive Separation, Analytical Sciences, 2001, 17: i1105-1108 | |
| 7 | Speciation of rare earth elements in soil by sequential extraction then HPLC coupled with visible and ICP-MS detection, Fresenius Journal of Analytical Chemistry, 2001, 370(8): 1041-1047 | |
| 6 | 电化学氢化物发生法的进展及其在原子光谱分析中的应用, 分析化学, 2001, 29(8): 967-970 | |
| 5 | Preliminary study of existing species of lanthanum in the spinach leaves after being cultivated with a culture solution containing lanthanum, Analytical Sciences, 2001, 17(6): 789-791 | |
| 4 | Preliminary study on a vapor generation technique for nickel without using carbon monoxide by inductively coupled plasma atomic emission spectrometry, Spectrochimica Acta Part B-Atomic Spectroscopy, 2000, 55(7): 943-950 | |
| 3 | 软配位原子效应在锌和镉分离中的应用, 分析化学, 2000, 28(6): 759-763 | |
| 2 | Evaluation of dissolved species of lanthanum in the solutions containing different amino acids by cation-exchange chromatography coupled with electrospray ionization mass spectrometry, Analytical Sciences, 2000, 16(2): 241-244 | |
| 1 | Extracted species of rare earth elements using bis(1,1,3,3-tetramethylbutyl)phosphinic acid as an extractant and their effective mutual separation by high-performance extraction chromatography, Bulletin of the Chemical Society of Japan, 1999, 72(12): 2693-2697 | |
已申请专利
| 序号 | 专利名称 | 发明（设计）人 | 申请号 | 公开号 | 类型 |
|---|---|---|---|---|---|
| 29 | 一种抗体元素标签及其制备方法和应用 | 严晓文，王蕾，易立，王秋泉 | 202410844279.5 | CN118792386A | 发明专利 |
| 28 | 溶液原位原子荧光光谱分析装置 | 王秋泉，闫丽珍，杨利民 | 202410578651.2 | CN118294426A | 发明专利 |
| 27 | 磷化镓-氮掺杂二氧化钛可见光催化纳米复合材料及其制备方法和应用 | 王秋泉，闫丽珍，杨利民 | 202410032597.1 | CN117884160A | 发明专利 |
| 26 | 一种共价靶向砷抑制剂及其制备方法和应用 | 严晓文，赵阳，王秋泉 | 202210989763.8 | CN115322226A | 发明专利 |
| 25 | 一种砷-巯基分子信标化合物及其应用 | 严晓文，谢鹏 | 202210587979.1 | CN115819486A | 发明专利 |
| 24 | 一种光裂解砷-巯基标签化合物及其应用 | 严晓文，谢鹏 | 202210595752.1 | CN114835753A | 发明专利 |
| 23 | 一种三功能DOTA类螯合剂中间体的制备方法与应用 | 王秋泉，胡星旺，严晓文 | 202210732490.9 | CN115160244A | 发明专利 |
| 22 | 色谱与质谱联用的零死体积接口装置及其应用 | 王秋泉，周阳，宋杏蕊 | 202210559285.7 | CN114965831A | 发明专利 |
| 21 | 基于病毒衣壳蛋白纳米结构的化学信号放大倍增器及制备方法和应用 | 王秋泉，刘珍，袁榕，梁勇，葛赋春 | 202010336306.X | CN111505140A | 发明专利 |
| 20 | 基于金属有机框架材料的石英毛细管杂化整体柱的制备 | 王秋泉，丁萌 | 202010295871.6 | CN111359587A | 发明专利 |
| 19 | 无油分选-直接注入-ICPMS单细胞分析系统 | 王秋泉，周阳，陈张倩 | 202010158129.0 | CN111266140A | 发明专利 |
| 18 | 手持式一体化液相色谱仪 | 张博，史晓慧，王晓兵，孙楷越，吕纪键 | 201810808694.X | CN108593813A | 发明专利 |
| 17 | 一种虹吸式毛细管色谱分离法 | 张博，高凡，周拙恒，朱珏，黄山青，林丽缘 | 201710443289.8 | CN107037161A | 发明专利 |
| 16 | 一种多探头液质联用点板装置 | 张博，丁芳芳，史晓慧，曾巨星，黄山青 | 201610216186.3 | CN105891363A | 发明专利 |
| 15 | 一种纳米填料毛细管色谱微柱制备装置及其制备方法 | 张博，王林，周拙恒，刘娅 | 201410310772.5 | CN104034833B | 发明专利 |
| 14 | 一种反相色谱硅胶填料的制备方法 | 张博，王林，丁芳芳，王鑫，叶淋泉，徐灵佳 | 201410326763.5 | CN104069840B | 发明专利 |
| 13 | 万伏高压电场增强液相色谱系统 | 张博，叶淋泉，高凡，徐灵佳 | 201410154755.7 | CN103884814B | 发明专利 |
| 12 | 基于液滴微流控技术制备粒径均一可控色谱填料的方法 | 张博，王鑫，丁芳芳，王林，周拙恒 | 201410084209.0 | CN103816881B | 发明专利 |
| 11 | 一种基体辅助激光解吸离子源质谱的在线样品制备装置 | 张博，肖志良，王雪 | 201210086514.4 | CN102621253B | 发明专利 |
| 10 | 一种毛细管固相萃取微柱的制备方法 | 张博，肖志良，牛萌蕾 | 201110416485.9 | CN102513073B | 发明专利 |
| 9 | 用于蛋白质二维电泳分离的微流控芯片接口的制备方法 | 宋站雨，王秋泉，张博，陈宏 | 201110343112.3 | CN102504010A | 发明专利 |
| 8 | 可调式即时封装树木表皮采样器 | 王秋泉，张天闻，赵玉丽 | 200910112192.4 | CN101608980 | 发明专利 |
| 7 | 应用于连续流动体系中的气液分离器 | 邱建华，王秋泉 | 200620121485.0 | CN200948374 | 实用新型专利 |
| 6 | 便携式液相色谱仪 | 王秋泉，付强，徐振东 | 200610055109.0 | CN1815221 | 发明专利 |
| 5 | 用于便携式液相色谱仪检测系统的光纤组件 | 付强，王秋泉，徐振东 | 200620006301.6 | CN2874495 | 实用新型专利 |
| 4 | 紫外-可见吸收/荧光两用流通池 | 付强，王秋泉，罗世鹏，刘永玉 | 200610009153.8 | CN1815218 | 发明专利 |
| 3 | 可调式色谱微柱—流通池安装架 | 徐振东，付强，王秋泉 | 200620005095.7 | CN2874494 | 实用新型专利 |
| 2 | 十八烷基型整体式液相色谱微柱的制备方法 | 徐振东，王秋泉，付强 | 200610054640.6 | CN1833772 | 发明专利 |
| 1 | 辛基型微柱液相色谱整体柱的制备方法 | 黄晓佳，黄本立，王秋泉 | 200310121890.3 | CN1554945 | 发明专利 |
